The Role of Dominant Mutations in the Population Expansion
نویسندگان
چکیده
We have studied the dynamics of expansion of diploid, sexually reproducing populations onto new territories demanding different genetic adaptations. Populations succeeded in the new habitats if the mutations of alleles responsible for adaptation to the new conditions were recessive. If behind the hostile territory another friendly habitat exists, several different scenarios are possible, including one in which the middle, most hostile, habitat remains empty, separating populated two, more friendly, ones.
منابع مشابه
Detection of P 53 gene mutations in exons 5 and 8 in patients of familial breast cancer with PCR-SSCP methode.
Background: Breast cancer is one of the most common cancer of women in the world. Although different genetic alteration has been reported in this malignancy, but P 53 gene mutations has more frequency. P 53 gene is one of the most important suppressor genes and it play a central role in breast cancer and detecting of mutations in this gene would be very helpful in understanding of genetic m...
متن کاملAnalyzing the Role of Urban Land Policies on Urban Sprawl (case study: Sabzevar)
Extended Abstract Introduction Urban sprawl is considered as one of the well-known patterns of urban expansion, which means uncontrolled physical expansion of cities on agricultural land or undeveloped surrounding areas. What today is known as sprawl describes scattered and low-density urban expansion. Patterns of urban sprawl expansion could have adverse consequences, such as increas...
متن کاملMEFV Gene Variant Alleles in Normal Population of Northwest of Iran, Ardabil Province
Background & objectives: MEFV gene has a major role in Familial Mediterranean Fever (FMF) as an auto-inflammatory disorder. FMF is most often seen in the people of the Mediterranean area. Considering the significant role of the MEFV gene in many rheumatologic diseases and even non-rheumatologic disorders, it is necessary to identify different variations of these mutations in the healthy and nor...
متن کاملAssociation of Pathogenic Missense and Nonsense Mutations in Mitochondrial COII Gene with Familial Adenomatous Polyposis (FAP)
Nuclear genetic mutations have been extensively investigated in solid tumors. However, the role of the mitochondrial genome remains uncertain. Since the metabolism of solid tumors is associated with aerobic glycolysis and high lactate production, tumors may have mitochondrial dysfunctions. Familial adenomatous polyposis (FAP) is a rare form of colorectal cancer and an autosomal dominant inheri...
متن کاملInvestigation of LRTOMT gene (locus DFNB63) mutations in Iranian patients with autosomal recessive non-syndromic hearing loss
Hearing loss (HL) is the most frequent sensory defect affecting 1 in 1000 neonates. This can occur due to genetic or environmental causes or both. The genetic causes are very heterogenous and over 100 loci have been identified to cause autosomal recessive non - syndromic hearing loss (ARNSHL). The aim of this study was to determine the contribution of the LRTOMT gene mutations in causing ARNSHL...
متن کاملExon Sequencing of PKD1 Gene in an Iranian Patient with Autosomal-Dominant Polycystic Kidney Disease
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic kidney disorders with the incidence of 1 in 1,000 births. ADPKD is genetically heterogeneous with two genes identified: PKD1 (16p13.3, 46 exons) and PKD2 (4q21, 15 exons). Eighty five percent of the patients with ADPKD have at least one mutation in the PKD1 gene. Genetic studies have demonstrate...
متن کامل